P2 purinergic receptor modulation of cytokine production
نویسندگان
چکیده
منابع مشابه
P2 purinergic receptors: modulation of cell function and therapeutic potential.
In addition to its key role in cellular metabolism where it acts as a ubiquitous enzyme cofactor and as the key source of the cellular energy unique to phosphate bond formation, the purine nucleotide ATP (Fig. 1) also functions as a potent extracellular messenger producing its effects via the activation of a family of distinct cell surface receptors, the P2 receptor family (Ralevic and Burnstoc...
متن کاملP2-purinergic control of liver glycogenolysis.
Purinergic agonists cause a dose-dependent activation of glycogen phosphorylase in isolated rat hepatocytes. Half-maximally effective concentrations are 5 X 10(-7)M for ATP, 2 X 10(-6)M for ADP, and about 5 X 10(-5) M for AMP and adenosine. This potency series indicates the presence of P2-purinergic receptors. The mode of action of ATP appears to be identical with that of the Ca2+-dependent gly...
متن کاملThe P2 purinergic receptors of human dendritic cells: identification and coupling to cytokine release.
We investigated the expression of purinoceptors in human dendritic cells, providing functional, pharmacological, and biochemical evidence that immature and mature cells express P2Y and P2X subtypes, coupled to increase in the intracellular Ca(2+), membrane depolarization, and secretion of inflammatory cytokines. The ATP-activated Ca(2+) change was biphasic, with a fast release from intracellula...
متن کاملPerspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and Therapeutic Potential
In addition to its key role in cellular metabolism where it acts as a ubiquitous enzyme cofactor and as the key source of the cellular energy unique to phosphate bond formation, the purine nucleotide ATP (Fig. 1) also functions as a potent extracellular messenger producing its effects via the activation of a family of distinct cell surface receptors, the P2 receptor family (Ralevic and Burnstoc...
متن کاملModulation of cytokine production by carnitine
The ability of carnitine congeners to modulate cytokine production by human peripheral blood mononuclear cells (PBMC) was investigated. Modulation of cytokine production by PBMC of young (30 years of age or younger) and old (70 years of age or older) normal donors was first compared. The PBMC were collected over Ficoll-Hypaque and incubated in the presence of various concentrations of acetyl L-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2007
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-006-9034-y